Prolaktin
Navigatsiya qismiga oʻtish
Qidirish qismiga oʻtish
| Prolaktin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB mana bu asosida 1n9d. | |||||||||||||
| |||||||||||||
| Identifikatorsiyalash | |||||||||||||
| Simbol | PRL | ||||||||||||
| Tashqi ID | OMIM: 176760 MGI: 97762 HomoloGene: 732 GeneCards: PRL Gene | ||||||||||||
| |||||||||||||
| Ortologiya | |||||||||||||
| Turi | Odam | Sichqon | |||||||||||
| Entrez | 5617 | 19109 | |||||||||||
| Ensembl | ENSG00000172179 | ENSMUSG00000021342 | |||||||||||
| UniProt | P01236 | P06879 | |||||||||||
| RefSeq (мРНК) | NM_000948 | NM_001163530 | |||||||||||
| RefSeq (oqsil) | NP_000939 | NP_001157002 | |||||||||||
| Lokus (UCSC) |
Chr 6: 22.29 – 22.3 Mb |
Chr 13: 27.06 – 27.07 Mb | |||||||||||
| PubMedni qidirish | [1] | [2] | |||||||||||
Prolaktin (laktotropin nomi bilan ham ataladi) sut emizuvchilarda sut ishlab chiqarishni taʼminlashda asosiy rol oʻynaydigan proteindir. U turli umurtqalilarda, jumladan insonlarda 300 dan ortiq jarayonlarga taʼsir oʻtkazadi.[1] Prolaktin ovqatlanish, juftlashish, estrogenlar bilan davolash va ovulatsiyaga javoban gipofiz bezidan ishlab chiqariladi. Shuningdek, u metabolizm, immun sistemasi regulatsiyasi hamda meʼda osti bezi rivojlanishida muhim rol oʻynaydi.
Proklaktin 1930-yili Oscar Riddle[2] tomonidan inson boʻlmagan hayvonlarda kashf etilgan, 1970-yilda esa Henry Friesen tomonidan insonlarda tasdiqlangan.[3] Bundan tashqari, prolaktin PRL geni tomonidan kodlangan peptid gormoni hisoblanadi.[4]
Manbalar[tahrir | manbasini tahrirlash]
- ↑ "Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice". Endocrine Reviews 19 (3): 225–68. Jun 1998. doi:10.1210/edrv.19.3.0334. PMID 9626554.
- ↑ "The preparation of prolactin". Journal of Pharmacology and Experimental Therapeutics 55 (3): 365–371. November 1935. http://jpet.aspetjournals.org/content/55/3/365.abstract.
- ↑ "The biosynthesis of human growth hormone and prolactin". The Journal of Clinical Endocrinology and Metabolism 31 (6): 611–24. Dec 1970. doi:10.1210/jcem-31-6-611. PMID 5483096. http://jcem.endojournals.org/content/31/6/611.abstract.
- ↑ "Mapping of prolactin and tumor necrosis factor-beta genes on human chromosome 6p using lymphoblastoid cell deletion mutants". Somatic Cell and Molecular Genetics 15 (3): 203–13. May 1989. doi:10.1007/BF01534871. PMID 2567059.
Havolalar[tahrir | manbasini tahrirlash]
- Prolaktin. MedlinePlus Encyclopedia. (ingl.)
 | Bu andozani aniqrogʻiga almashtirish kerak. |
