Prolaktin

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Prolaktin
PRL structure.png
PDB mana bu asosida 1n9d.
Foydalanish mumkin bo‘lgan tuzilmalar
PDB Ortologiyani qidirish: PDBe, RCSB
Identifikatorsiyalash
Simbol PRL
Tashqi ID OMIM: 176760 MGI97762 HomoloGene: 732 GeneCards: PRL Gene
Ortologiya
Turi Odam Sichqon
Entrez 5617 19109
Ensembl ENSG00000172179 ENSMUSG00000021342
UniProt P01236 P06879
RefSeq (мРНК) NM_000948 NM_001163530
RefSeq (oqsil) NP_000939 NP_001157002
Lokus (UCSC) Chr 6:
22.29 – 22.3 Mb
Chr 13:
27.06 – 27.07 Mb
PubMedni qidirish [1] [2]

Prolaktin (laktotropin nomi bilan ham ataladi) sut emizuvchilarda sut ishlab chiqarishni taʼminlashda asosiy rol oʻynaydigan proteindir. U turli umurtqalilarda, jumladan insonlarda 300 dan ortiq jarayonlarga taʼsir oʻtkazadi.[1] Prolaktin ovqatlanish, juftlashish, estrogenlar bilan davolash va ovulatsiyaga javoban gipofiz bezidan ishlab chiqariladi. Shuningdek, u metabolizm, immun sistemasi regulatsiyasi hamda meʼda osti bezi rivojlanishida muhim rol oʻynaydi.

Proklaktin 1930-yili Oscar Riddle[2] tomonidan inson boʻlmagan hayvonlarda kashf etilgan, 1970-yilda esa Henry Friesen tomonidan insonlarda tasdiqlangan.[3] Bundan tashqari, prolaktin PRL geni tomonidan kodlangan peptid gormoni hisoblanadi.[4]

Manbalar[tahrir | manbasini tahrirlash]

  1. "Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice". Endocrine Reviews 19 (3): 225–68. Jun 1998. doi:10.1210/edrv.19.3.0334. PMID 9626554. 
  2. "The preparation of prolactin". Journal of Pharmacology and Experimental Therapeutics 55 (3): 365–371. November 1935. http://jpet.aspetjournals.org/content/55/3/365.abstract. 
  3. "The biosynthesis of human growth hormone and prolactin". The Journal of Clinical Endocrinology and Metabolism 31 (6): 611–24. Dec 1970. doi:10.1210/jcem-31-6-611. PMID 5483096. http://jcem.endojournals.org/content/31/6/611.abstract. 
  4. "Mapping of prolactin and tumor necrosis factor-beta genes on human chromosome 6p using lymphoblastoid cell deletion mutants". Somatic Cell and Molecular Genetics 15 (3): 203–13. May 1989. doi:10.1007/BF01534871. PMID 2567059. 

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