Gonadoliberin

GNRH1
Identifikatorlar
Nomenklatura	GNRH1, GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone
Tashqi IDlar	OMIM: 152760 MGI: 95789 HomoloGene: 641 GeneCards: GNRH1
Gen joylashuvi (odam)
Xr.	Chromosome 8 (human)
Oxir.	25,424,654 bp
Gen joylashuvi (sichqon)
Xr.	Chromosome 14 (mouse)
Oxir.	67,986,888 bp
RNK ekspressiyasi profili
	Top expressed in
	tibial nerve; ; Moyak; ; cerebellar hemisphere; ; putamen; ; ascending aorta; ; Descending thoracic aorta; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; popliteal artery; ; tibial arteries;
	Top expressed in
	primary oocyte; ; Koʻmik; ; embryonic cell; ; Zigota; ; secondary oocyte; ; morula; ; neural layer of retina; ; Granulotsitlar; ; thymus; ; preoptic area;
	More reference expression data
	More reference expression data
Gen ontologiyasi
Molecular function	hormone activity; gonadotropin hormone-releasing hormone activity; gonadotropin-releasing hormone receptor binding;
Cellular component	axon terminus; perikaryon; Golgi-associated vesicle; extracellular region; neurosecretory vesicle; Dendrit; Mitoxondriya; neuron projection; cytoplasmic side of rough endoplasmic reticulum membrane; extracellular space;
Biological process	negative regulation of immature T cell proliferation; response to prolactin; negative regulation of neuron migration; response to potassium ion; response to organic cyclic compound; response to testosterone; estrous cycle; female pregnancy; cell-cell signaling; response to steroid hormone; ageing; response to peptide hormone; negative regulation of apoptotic process; male sex determination; multicellular organism development; response to prostaglandin E; response to lipopolysaccharide; response to corticosteroid; regulation of gene expression; ovarian cycle; response to ethanol; regulation of ovarian follicle development; signal transduction; negative regulation of cell population proliferation; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; Koʻpayish;
	Sources:Amigo / QuickGO
Ortologiya
	2796
	14714
	ENSG00000147437
	ENSMUSG00000015812
	P01148
	P13562
	NM_001083111; NM_000825
	NM_008145
	NP_000816; NP_001076580
	NP_032171
	Vikimaʼlumotlar
koʻrish/tahrirlash (odam)	koʻrish/tahrirlash (sichqon)

Gonadotropin-ajralishini boshqaruvchi gormon (GnRH) — gipofizning oldingi boʻlagidan follikulani stimullovchi gormon va lyuteinlashtiruvchi gormon ajralishini boshqaruvchi gormon. U gipotalamus gipotalamik sohadagi GnRH neyronlari tomonidan sintez qilinadi va ajratiladi. GnRH peptid gormon boʻlib, gipotalamus–gipofiz–jinsiy bezlar o‘qi faoliyatining boshlangʻich bosqichida ishtirok etadi.

GnRH taʼsiri testosteron tomonidan susaytiriladi. U gonadotropin-ajralishini boshqaruvchi gormonlar oilasiga mansub.

Gonadotropin-ajralishini boshqaruvchi gormonning GnRH2 va GnRH3 kabi boshqa turlari ham mavjud. Biroq odamlarda gipofiz faoliyatini boshqarishda aynan **GnRH1** ishtirok etadi. Shu sababli, inson fiziologiyasi haqida soʻz borganda, GnRH1 odatda qisqacha **GnRH** deb ataladi^[5].

Manbalar

1 2 3 GRCh38: Ensembl release 89: ENSG00000147437 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015812 - Ensembl, May 2017
↑ „Human PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ „Mouse PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ „Physiology of GnRH and gonadotrophin secretion“, Endotext [internet], 2024-10-15.

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Bu andozani aniqrogʻiga almashtirish kerak.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000147437 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015812 - Ensembl, May 2017

[3] „Human PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] „Mouse PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] „Physiology of GnRH and gonadotrophin secretion“, Endotext [internet], 2024-10-15.

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