2-dehidro-3-deoksi-D-glyukonat 5-degidrogenaza

Enzimologiyada 2-degidro-3-deoksi-D-glyukonat 5-degidrogenaza (EC)) kimyoviy reaksiyani katalizlovchi ferment hisoblanadi.

2-degidro-3-deoksi-D-glyukonat + NAD ⁺ $\rightleftharpoons$ (4S) −4,6-digidroksi-2,5-dioksogeksanoat + NADH + H ⁺

Shunday qilib, bu fermentning ikkita substrati 2-dehidro-3-deoksi-D-glyukonat va NAD <sup id="mwFA">+</sup>, uning 3 ta oxirgi mahsuloti esa (4S) −4,6-dihidroksi-2,5-dioksogeksanoat, NADH va H <sup id="mwGQ">+</sup> hisoblanadi.

Bu ferment pentoza va glyukuronat oʻzaro konversiyalarida ishtirok etadi.

Nomenklaturasi

Bu ferment oksidoreduktazalar oilasiga, xususan donorning CH-OH guruhiga NAD ⁺ yoki NADP ⁺ akseptor sifatida taʼsir etuvchi fermentlarga tegishli. Ushbu ferment sinfining tizimli nomi 2-dehidro-3-deoksi-D-glyukonat: NAD ⁺ 5-oksidoredüktaza. Umumiy qoʻllaniladigan boshqa nomlar orasida 2-keto-3-deoksiglyukonat 5-degidrogenaza, 2-keto-3-deoksi-D-glyukonat degidrogenaza, 2-keto-3-deoksiglyukonat (nikotinamid adenin dinukleotid, (fosfat)) dehidrogenaza, 2- keto-3-deoksi-D-glyukonat (3-deoksi-D-glisero-2,5-hexodiulosonic va kislota) degidrogenaza kabilari keng qoʻllaniladi.

Manbalar

• Condemine G; Hugouvieux-Cotte-Pattat N; Robert-Baudouy J (1984). "An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase". J. Gen. Microbiol. 130: 2839–2844. doi:10.1099/00221287-130-11-2839. 
• "Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2, 5-hexodiulosonic acid". The Journal of Biological Chemistry 238: 1577–83. May 1963. PMID 13986017. https://archive.org/details/sim_journal-of-biological-chemistry_1963-05_238_5/page/1577.