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Catharanthus roseus: Versiyalar orasidagi farq

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„Catharanthus roseus“ sahifasi tarjima qilib yaratildi
(Farq yoʻq)

2-Noyabr 2022, 14:37 dagi koʻrinishi

Catharanthus roseus
Ilmiy tasniflash
Plantae
Tracheophytes
Angiosperms
Eudicots
Asterids
Gentianales
Apocynaceae
Catharanthus
C. roseus
Binar nomi
Catharanthus roseus

Sinonimlar
  • Vinca rosea L.
  • Pervinca rosea (L.) Gaterau
  • Lochnera rosea (L.) Rchb. ex Spach
  • Ammocallis rosea (L.) Small

(See also Synonyms section)

Markazi sariq rangli oq C. roseus gul

Catharanthus roseus chaqnoq ko'zlar, koʻz oʻsimligi, qabriston oʻsimligi, Madagaskar oʻsimligi, keksa xizmatkor, pushti gulqogʻoz nomlari bilan mashhur Apocynaceae oilasiga mansub gulli oʻsimlik turi. Bu o‘simlik Madagaskarda kelib chiqqan va endemik tur hisoblanadi. Ammo boshqa joylarda bezak va dorivor o'simlik sifatida o'stiriladi. Bu o‘simlikdan saraton kasalligini davolashda ishlatiladigan vinkristin va vinblastin preparatlari olinadi[2]. Ilgari Vinca rosea sifatida Vinca turkumiga kiritilgan.

Uning xalq orasida tarqalgan ko‘plab nomlari bor, ular orasida arivotaombelona yoki rivotambelona, tonga, tongatse yoki trongatse, tsimatiririnina va vonenina mavjud[3].

Tavsif

Catharanthus roseus — doim yashil yarim buta yoki oʻt oʻsimlik bo‘yi 1 m (39 in) gacha yetadi. Barglari oval cho'zinchoq, uxuuzunligi 2.5–9 cm (1.0–3.5 in), kengligi 1–3.5 cm (0.4–1.4 in) yaltiroq yashil, tuksiz, qarama-qarshi juftlikda joylashgan[4][5][6][7].

Ekologiya

Yovvoyi tabiatda C. roseus yoʻqolib ketish xavfi ostida turgan oʻsimlik hisoblanadi. Biroq, u Avstraliya, Bangladesh, Hindiston, Malayziya, Pokiston va Amerika Qo'shma Shtatlari kabi dunyoning subtropik va tropik hududlarida keng tarqalgan va tabiiylashtirilgan[4]. U Avstraliyada o'sishga shunchalik yaxshi moslashganki, G'arbiy Avstraliya va Avstraliya poytaxti hududi [8] va Kvinslendning sharqiy qismlarida zararli begona o'tlar ro'yxatiga kiritilgan[9].

Qizil markazli navli och pushti

Kultivatsiya

Manzarali o'simlik sifatida u quruq va ozuqaviy jihatdan tanqis sharoitlarda chidamliligi uchun qadrlanad. To'liq quyosh va yaxshi quritilgan tuproqni afzal ko‘radi. Gul rangining o'zgarishi (oq, binafsha, shaftoli, qizil va qizil-to'q sariq), shuningdek, mo'tadil mintaqalarda sovuq o'sish sharoitlariga chidamliligi uchun ko'plab navlar tanlangan. Diqqatga sazovor navlar orasida "Albus" (oq gullar), "Uzum sovutgichi" (atirgul-pushti; sovuqqa chidamli), Ocellatus guruhi (turli xil ranglar) va "Yalpiz sovutgichi" (o'rtasi qizil; sovuqqa chidamli)[4]. AQShda u ko'pincha "Vinka" deb nomlanadi, ammo botaniklar uning identifikatsiyasini o'zgartirgan va ko'pincha janubda yo'llar bo'ylab o'sib borayotganini ko'rish mumkin.

Buyuk Britaniyada u Qirollik bog'dorchilik jamiyatining bog'dagi xizmatlari uchun mukofotiga sazovor bo'ldi[10](2017-yilda tasdiqlangan)[11].

Foydalanadi

An'anaviy

Bu tur uzoq vaqtdan beri dorivor o‘simlik sifatida yetishtiriladi[12]. Ayurvedada (Hind an'anaviy tibbiyoti) uning ildizlari va kurtaklari ekstrakti zaharli bo'lsa-da, bir qancha kasalliklarga qarshi ishlatiladi. An'anaviy xitoy tabobatida undan olingan ekstraktlar diabet, bezgak va Xodgkin limfomasi kabi ko'plab kasalliklarga qarshi ishlatilgan[5]. 1950-yillarda vinka alkaloidlari, jumladan, vinblastin va vinkristin, diabetga qarshi dori-darmonlarni tekshirish paytida Catharanthus roseusdan ajratib olingan[13]. Ushbu tasodifiy kashfiyot vinblastin va vinkristinning kimyoterapevtik ta'siri bo'yicha tadqiqotlarni kuchaytirishga olib keldi. G'arb farmatsevtika kompaniyalari tomonidan 2001-yilda C. roseus tomonidan ishlab chiqarilgan dori-darmonlarga nisbatan tarixiy mahalliy foydalanish va patent o'rtasidagi ziddiyat biopiratlikda ayblanishiga olib keldi[14].

Dorivor

Vinblastin va vinkristin, bir nechta saraton turlarini davolash uchun ishlatiladigan kimyoterapiya dori-darmonlari o'simlikda mavjud[15][16][17][18] va katarantin va vindolin alkaloidlarining birikmasidan biosintezlanadi[19]. Kichik hujayrali o'pka saratonini davolashda qo'llaniladigan yangi yarim sintetik kimyoterapevtik vosita vinorelbin[17][20] vindolin va katarantin[17][21][22] yoki vinka alkaloid leyrozidan tayyorlanishi mumkin[23]. O'simlikdan insulinni ogohlantiruvchi vinkolin ajratilgan[24][25].

Periwinkle butasi
Dark pink colour
Turli xil ranglarda keladi

Biologiya

Rosinidin - C. roseus gullarida topilgan pushti antosiyanidin pigmentidir[26]. Loxneritsin ildizlar tarkibida uchrovchi alkaloid[27].

Toksiklik

C. roseus, agar odamlar tomonidan og'iz orqali iste'mol qilinsa, juda zaharli bo'lishi mumkin. O'simlikning barcha qismlari zaharli hisoblanadi. Iste'mol qilingandagi simptomlar yengil oshqozon kramplari, yurak asoratlari, gipotenziya, tizimli falajdan iborat bo'lib, natijada o'limga olib keladi[28].

Fransuz botanigi Per Botoning so'zlariga ko'ra, uning zaharli xususiyatlari meksikaliklarga qadimdan ma'lum bo'lgan. Bu gulning nomlaridan biri bo'lgan vonenina, Malagasy tilidan “tavba guli” degan ma’noni anglatadi[29].

Galereya

  • Binafsha rangli Catharanthus roseus
    Binafsha rangli Catharanthus roseus
  • Bu Bangladeshda uyning balkonidagi gulli vannada manzarali o'simlik sifatida o'stirilgan.
    Bu Bangladeshda uyning balkonidagi gulli vannada manzarali o'simlik sifatida o'stirilgan.
  • Oq rangdagi Catharanthus roseus
    Oq rangdagi Catharanthus roseus
  • Oq Catharanthus roseus
    Oq Catharanthus roseus
  • Qizil Catharanthus roseus
    Qizil Catharanthus roseus
  • Oq qizg'ish periwinkle
    Oq qizg'ish periwinkle
  • Keraladagi Catharanthus roseus
    Keraladagi Catharanthus roseus
  • Binafsha rangli Catharanthus roseus
    Binafsha rangli Catharanthus roseus
  • Vinka Bangladeshning Koks- bozoridagi bog'dan
    Vinka Bangladeshning Koks- bozoridagi bog'dan
  • Bangladeshning Ishvardi shahrida joylashgan Catharanthus roseus
    Bangladeshning Ishvardi shahrida joylashgan Catharanthus roseus
  • G'arbiy Bengaliyadagi gul kurtaklari, Hindiston
    G'arbiy Bengaliyadagi gul kurtaklari, Hindiston
  • Hindiston
    Hindiston
  • Hindistonda keng tarqalgan bog 'o'simlik
    Hindistonda keng tarqalgan bog 'o'simlik
  • Pokistondagi Catharanthus roseus
    Pokistondagi Catharanthus roseus
  • Malayziyada yetishtiriladi
    Malayziyada yetishtiriladi
  • Hindiston ibodatxonalarida o'stirilgan gulli o'simlik
    Hindiston ibodatxonalarida o'stirilgan gulli o'simlik
  • Meva va urug'lar
    Meva va urug'lar
  • Madagaskardagi pishgan mevalari
    Madagaskardagi pishgan mevalari
  • Madagaskar periwinkle pishmagan mevalari
    Madagaskar periwinkle pishmagan mevalari
  • Tinch okeani Burgundiya Halo - Madagaskar Periwinkle
    Tinch okeani Burgundiya Halo - Madagaskar Periwinkle
  • Madagaskar qizil gulli nav
    Madagaskar qizil gulli nav
  • Yangi Dehlidagi qozonli o'simlik
    Yangi Dehlidagi qozonli o'simlik
  • Anter
    Anter

Ma'lumotnomalar

  1. ↑ "Catharanthus roseus". World Checklist of Selected Plant Families (WCSP). Royal Botanic Gardens, Kew. Retrieved 4 August 2019.
  2. ↑ Moudi, Maryam; Go, Rusea; Yien, Christina Yong Seok; Nazre, Mohd. (2013-11-04). "Vinca Alkaloids". International Journal of Preventive Medicine 4 (11): 1231–1235. ISSN 2008-7802. PMID 24404355. PMC 3883245. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3883245. 
  3. ↑ de La Beaujardière, Jean-Marie, ed (2001). "Botanical scientific bames" (en). Malagasy Dictionary and Malagasy Encyclopedia. https://en.mondemalgache.org/bins/taxonLists?kingdom=B&order=1&range=C#catharanthusroseus. 
  4. ↑ 4,0 4,1 4,2 Huxley, A., ed. (1992).
  5. ↑ 5,0 5,1 Flora of China: Catharanthus roseus
  6. ↑ College of Micronesia: Catharanthus roseus
  7. ↑ Jepson Flora: Catharanthus roseus
  8. ↑ „Catharanthus roseus“. Orpheus Island Research Station – James Cook University. Qaraldi: 2015-yil 2-noyabr.
  9. ↑ „Factsheet – Catharanthus roseus“. Queensland Government. Qaraldi: 2015-yil 2-noyabr.
  10. ↑ „RHS Plantfinder - Catharanthus roseus“. Qaraldi: 2018-yil 12-yanvar.
  11. ↑ „AGM Plants - Ornamental“. Royal Horticultural Society (2017-yil iyul). Qaraldi: 2018-yil 24-yanvar.
  12. ↑ Nejat, Naghmeh; Valdiani, Alireza; Cahill, David; Tan, Yee-How; Maziah, Mahmood; Abiri, Rambod (2015). "Ornamental Exterior versus Therapeutic Interior of Madagascar Periwinkle ( Catharanthus roseus ): The Two Faces of a Versatile Herb" (en). The Scientific World Journal 2015: 982412. doi:10.1155/2015/982412. ISSN 2356-6140. PMID 25667940. PMC 4312627. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4312627. 
  13. ↑ Heijden, Robert; Jacobs, Denise; Snoeijer, Wim; Hallard, Didier; Verpoorte, Robert (2004-03-01). "The Catharanthus Alkaloids:Pharmacognosy and Biotechnology". Current Medicinal Chemistry 11 (5): 607–628. doi:10.2174/0929867043455846. ISSN 0929-8673. PMID 15032608. http://dx.doi.org/10.2174/0929867043455846. 
  14. ↑ Karasov, Corliss (2001). "Who Reaps the Benefits of Biodiversity?". Environmental Health Perspectives 109 (12): A582–A587. doi:10.2307/3454734. PMID 11748021. PMC 1240518. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1240518. 
  15. ↑ Gansäuer, Andreas „Reductive C—C bond formation after epoxide opening via electron transfer“,. Metal Catalyzed Reductive C—C Bond Formation: A Departure from Preformed Organometallic Reagents, Topics in Current Chemistry Krische: . Springer Science & Business Media, 2007 — 25–52 bet. DOI:10.1007/128_2007_130. ISBN 978-3-540-72879-5. 
  16. ↑ Cooper, Raymond „Africa's gift to the world“,. Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press, 2016 — 46–51 bet. ISBN 978-1-4987-0430-4. 
  17. ↑ 17,0 17,1 17,2 Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules 17 (5): 5893–5914. doi:10.3390/molecules17055893. PMID 22609781. PMC 6268133. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6268133. 
  18. ↑ Raviña, Enrique „Vinca alkaloids“,. The evolution of drug discovery: From traditional medicines to modern drugs. John Wiley & Sons, 2011 — 157–159 bet. ISBN 978-3-527-32669-3. 
  19. ↑ Hirata, K. „Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures“,. Biotechnology in Agriculture and Forestry 26, Medicinal and Aromatic Plants Bajaj: . Springer-Verlag, 1994 — 46–55 bet. ISBN 978-3-540-56391-4. 
  20. ↑ Faller, Bryan A.; Pandi, Trailokya N. (2011). "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology 5: 131–144. doi:10.4137/CMO.S5074. PMID 21695100. PMC 3117629. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3117629. 
  21. ↑ Hardouin, Christophe; Doris, Eric; Rousseau, Bernard; Mioskowski, Charles (2002). "Concise synthesis of anhydrovinblastine from leurosine". Organic Letters 4 (7): 1151–1153. doi:10.1021/ol025560c. PMID 11922805. 
  22. ↑ Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guénard, Daniel; Guéritte, Françoise (2009). "Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids". Journal of Medicinal Chemistry 52 (1): 134–142. doi:10.1021/jm801064y. PMID 19072542. 
  23. ↑ Hardouin, Christophe; Doris, Eric; Rousseau, Bernard; Mioskowski, Charles (2002). "Concise synthesis of anhydrovinblastine from leurosine". Organic Letters 4 (7): 1151–1153. doi:10.1021/ol025560c. PMID 11922805. 
  24. ↑ Aynilian, GH; Weiss, SG; Cordell, GA; Abraham, DJ; Crane, FA; Farnsworth, NR (1974). "Catharanthus alkaloids. XXIX. Isolation and structure elucidation of vincoline". Journal of Pharmaceutical Sciences 63 (4): 536–8. doi:10.1002/jps.2600630409. PMID 4828700. 
  25. ↑ Yao, XG; Chen, F; Li, P; Quan, L; Chen, J; Yu, L; Ding, H; Li, C et al. (2013). "Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models". Journal of Ethnopharmacology 150 (1): 285–97. doi:10.1016/j.jep.2013.08.043. PMID 24012527. 
  26. ↑ Toki, Kenjiro; Saito, Norio; Irie, Yuki; Tatsuzawa, Fumi; Shigihara, Atsushi; Honda, Toshio (2008). "7-O-Methylated anthocyanidin glycosides from Catharanthus roseus". Phytochemistry 69 (5): 1215–1219. doi:10.1016/j.phytochem.2007.11.005. PMID 18164044. 
  27. ↑ „American Society of Plant Biologists“. August 2018.
  28. ↑ „Is Periwinkle Plant Poisonous or Toxic?“ (2020-yil 9-iyun).
  29. ↑ Boiteau, Pierre (1999). "vonenina" (fr). Dictionnaire des noms malgaches de végétaux. IV. Editions Alzieu. https://en.mondemalgache.org/bins/teny2/vonenina.  
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