Kontent qismiga oʻtish

David Julius: Versiyalar orasidagi farq

Vikipediya, ochiq ensiklopediya
Tarixni interaktiv tarzda koʻrib chiqish
Keyingi tahrir →
Kontent oʻchirildi Kontent qoʻshildi
VizualVikimatn
„David Julius“ sahifasi tarjima qilib yaratildi
 
„David Julius“ sahifasi tarjima qilib yaratildi
Qator 3: Qator 3:
[[Category:Articles with hCards]]
[[Category:Articles with hCards]]


'''Devid Jey Julius''' (1955 yil 4-noyabrda tug'ilgan) - amerikalik [[Fiziologiya|fiziolog]] va [[Nobel mukofoti]] laureati, [[Ogʻriq|og'riq]] hissi va issiqlikning [[Molekulyar biologiya|molekulyar mexanizmlari]], shu jumladan kapsaitsin, [[mentol]] va haroratni aniqlaydigan TRPV1 va TRPM8 retseptorlarining tavsifi bo'yicha ishi bilan mashhur. U San-Frantsiskodagi Kaliforniya universiteti professori, .

Julius 2010 yilda [[Hayot haqida fan]]<nowiki/>lar va [[tibbiyot]] bo'yicha Shou mukofotini va 2020 yilgi hayot fanlari bo'yicha yutuq mukofotini qo'lga kiritdi. <ref>{{Veb manbasi|sarlavha=Julius Named to Receive the Shaw Prize|url=http://www.ucsf.edu/news/2010/05/5991/julius-named-receive-shaw-prize|ish=ucsf.edu|kirish sanasi=December 5, 2016|arxivsana=April 29, 2019|arxivurl=https://web.archive.org/web/20190429011753/https://www.ucsf.edu/news/2010/05/5991/julius-named-receive-shaw-prize}}</ref> <ref>{{Veb manbasi|sarlavha=David Julius, PhD 49th Faculty Research Lecture Award|url=http://senate.ucsf.edu/2005-2006/frl-2005-2006.html|ish=senate.ucsf.edu|kirish sanasi=December 5, 2016|arxivsana=August 1, 2020|arxivurl=https://web.archive.org/web/20200801154215/https://senate.ucsf.edu/2005-2006/frl-2005-2006.html}}</ref> U Ardem Patapoutyan bilan birgalikda [[Fiziologiya va tibbiyot boʻyicha Nobel mukofoti|fiziologiya yoki tibbiyot bo'yicha 2021 yilgi Nobel mukofotiga sazovor bo'lgan]] . <ref>{{Veb manbasi|url=https://www.nobelprize.org/prizes/medicine/2021/summary/|sarlavha=The Nobel Prize in Physiology or Medicine 2021|ish=NobelPrize.org|kirish sanasi=October 4, 2021|arxivsana=October 4, 2021|arxivurl=https://web.archive.org/web/20211004114036/https://www.nobelprize.org/prizes/medicine/2021/press-release/?related=1&_pjax=%23pjax-well}}</ref>

== Erta hayot va ta'lim ==
Yuliy [[Ashkenazilar]] oilasida ( Rossiyadan ) Brighton Beach, Bruklin, [[New York (shahar)|Nyu-York]] shahrida tug'ilgan <ref>{{Veb manbasi|muallif=Hanau|ism=Shira|url=https://www.jta.org/2021/10/04/united-states/scientist-david-julius-whose-grandparents-fled-antisemitism-in-czarist-russia-wins-nobel-prize-in-medicine|sarlavha=Scientist David Julius, whose grandparents fled antisemitism in Czarist Russia, wins Nobel Prize in medicine|ish=Jewish Telegraphic Agency|sana=October 4, 2021|kirish sanasi=October 4, 2021}}</ref> u erda Avraam Linkoln o'rta maktabida o'qigan . <ref name="nyta">{{Yangiliklar manbasi |last=Mueller |first=Benjamin |last2=Santora |first2=Marc |last3=Engelbrecht |first3=Cora |date=October 4, 2021 |title=Nobel Prize Awarded for Research About Temperature and Touch |work=New York Times |url=https://www.nytimes.com/2021/10/04/health/nobel-prize-medicine-physiology-temperature-touch.html?smid=tw-share |access-date=October 5, 2021}}</ref> 1977 yilda [[Massachusetts texnologiya instituti|Massachusets texnologiya institutida]] bakalavr darajasini oldi. U 1984 yilda [[California universiteti, Berkeley|Berkli Kaliforniya universitetida]] Jeremi Torner va Rendi Shekmanning birgalikdagi rahbarligi ostida doktorlik darajasini oldi, u yerda Kex2 ni furinga o'xshash proprotein konvertazalarining asosi ekanligini aniqladi. 1989 yilda u [[Columbia universiteti|Kolumbiya universitetida]] Richard Axel bilan doktorlikdan keyingi ta'limni tugatdi va u yerda serotonin 1c retseptorini klonlash va tavsiflash imkoniga ega bo'ldi. <ref>{{Cite journal|last=Julius|first1=D.|last2=MacDermott|first2=A. B.|last3=Axel|first3=R.|last4=Jessell|first4=T. M.|date=July 29, 1988|title=Molecular characterization of a functional cDNA encoding the serotonin 1c receptor|journal=Science|volume=241|issue=4865|pages=558–564|issn=0036-8075|pmid=3399891|doi=10.1126/science.3399891|bibcode=1988Sci...241..558J}}</ref>

Berkli va Kolumbiyada bo'lganida, Yuliy silosibin qo'ziqorinlari va lisergik kislota dietilamidining qanday ishlashi bilan qiziqdi, bu esa uni tabiatdagi narsalarning inson retseptorlari bilan o'zaro ta'sirini kengroq o'rganishga olib keldi. <ref name="nyta">{{Yangiliklar manbasi |last=Mueller |first=Benjamin |last2=Santora |first2=Marc |last3=Engelbrecht |first3=Cora |date=October 4, 2021 |title=Nobel Prize Awarded for Research About Temperature and Touch |work=New York Times |url=https://www.nytimes.com/2021/10/04/health/nobel-prize-medicine-physiology-temperature-touch.html?smid=tw-share |access-date=October 5, 2021}}<cite class="citation news cs1" data-ve-ignore="true" id="CITEREFMuellerSantoraEngelbrecht2021">Mueller, Benjamin; Santora, Marc; Engelbrecht, Cora (October 4, 2021). </cite></ref>

== Tadqiqot karerasi ==
[[Fayl:22_Hegasy_EN_Nobel_Prize_2021_TRPV1_Piezo2.png|thumb| Nobel mukofoti ishi]]
U oʻz faoliyatini 1989-yilda San-Fransiskodagi Kaliforniya universitetida oʻqituvchi sifatida boshlagan <ref>{{Veb manbasi|sarlavha=David Julius '77 shares the Nobel Prize in physiology or medicine|url=https://news.mit.edu/2021/david-julius-77-shares-nobel-prize-physiology-medicine-1004|kirish sanasi=2021-10-07|ish=MIT News {{!}} Massachusetts Institute of Technology|til=en}}</ref> <ref>{{Veb manbasi|sarlavha=The Nobel Prize in Physiology or Medicine 2021|url=https://www.nobelprize.org/prizes/medicine/2021/press-release/|kirish sanasi=2021-10-07|ish=NobelPrize.org|til=en-US}}</ref> 1997 yilda Yuliyning laboratoriyasi TRPV1 ni klonladi va tavsifladi, bu orqali u chili qalampirini "achchiq" qiladi kapsaitsinni aniqlaydigan retseptorni kashf etdi, . <ref name=":0">{{Cite journal|last=Caterina|first1=M. J.|last2=Schumacher|first2=M. A.|last3=Tominaga|first3=M.|last4=Rosen|first4=T. A.|last5=Levine|first5=J. D.|last6=Julius|first6=D.|date=October 23, 1997|title=The capsaicin receptor: a heat-activated ion channel in the pain pathway|journal=Nature|volume=389|issue=6653|pages=816–824|doi=10.1038/39807|issn=0028-0836|pmid=9349813|bibcode=1997Natur.389..816C}}</ref> Ular TRPV1 zararli issiqlikni ham aniqlashini aniqladilar ( termotseptsiya ). <ref name=":0" /> <ref>{{Cite journal|last=Tominaga|first1=M.|last2=Caterina|first2=M. J.|last3=Malmberg|first3=A. B.|last4=Rosen|first4=T. A.|last5=Gilbert|first5=H.|last6=Skinner|first6=K.|last7=Raumann|first7=B. E.|last8=Basbaum|first8=A. I.|last9=Julius|first9=D.|date=September 1998|title=The cloned capsaicin receptor integrates multiple pain-producing stimuli|journal=Neuron|volume=21|issue=3|pages=531–543|issn=0896-6273|pmid=9768840|doi=10.1016/S0896-6273(00)80564-4}}</ref> TRPV1 tizimli ravishda bog'liq bo'lgan TRP (o'tkinchi retseptor potentsiali) kation kanallarining katta oilasining bir qismidir. TRPV1 (oqsilning genetik nokautlari yordamida) yo'q hayvonlar zararli issiqlik va kapsaitsinga sezgirligini yo'qotadi. <ref>{{Cite journal|last=Caterina|first1=M. J.|last2=Leffler|first2=A.|last3=Malmberg|first3=A. B.|last4=Martin|first4=W. J.|last5=Trafton|first5=J.|last6=Petersen-Zeitz|first6=K. R.|last7=Koltzenburg|first7=M.|last8=Basbaum|first8=A. I.|last9=Julius|first9=D.|date=April 14, 2000|title=Impaired nociception and pain sensation in mice lacking the capsaicin receptor|journal=Science|volume=288|issue=5464|pages=306–313|issn=0036-8075|pmid=10764638|doi=10.1126/science.288.5464.306|bibcode=2000Sci...288..306C}}</ref>

Yuliyning laboratoriyasi, shuningdek, TRP super oilasining a'zolari bo'lgan TRPM8 (CMR1) va TRPA1 ni klonladi va tavsifladi. Ular TRPM8 [[mentol]] va sovuqroq haroratni aniqlashini <ref>{{Cite journal|last=McKemy|first1=David D.|last2=Neuhausser|first2=Werner M.|last3=Julius|first3=David|date=March 7, 2002|title=Identification of a cold receptor reveals a general role for TRP channels in thermosensation|journal=Nature|volume=416|issue=6876|pages=52–58|doi=10.1038/nature719|issn=0028-0836|pmid=11882888|bibcode=2002Natur.416...52M}}</ref> <ref>{{Cite journal|last=Bautista|first1=Diana M.|last2=Siemens|first2=Jan|last3=Glazer|first3=Joshua M.|last4=Tsuruda|first4=Pamela R.|last5=Basbaum|first5=Allan I.|last6=Stucky|first6=Cheryl L.|last7=Jordt|first7=Sven-Eric|last8=Julius|first8=David|date=July 12, 2007|title=The menthol receptor TRPM8 is the principal detector of environmental cold|journal=Nature|volume=448|issue=7150|pages=204–208|doi=10.1038/nature05910|issn=1476-4687|pmid=17538622|bibcode=2007Natur.448..204B}}</ref> va TRPA1 xantal moyini (allil izotiosiyanat) aniqlashini ko'rsatdi. <ref>{{Cite journal|last=Jordt|first1=Sven-Eric|last2=Bautista|first2=Diana M.|last3=Chuang|first3=Huai-Hu|last4=McKemy|first4=David D.|last5=Zygmunt|first5=Peter M.|last6=Högestätt|first6=Edward D.|last7=Meng|first7=Ian D.|last8=Julius|first8=David|date=January 15, 2004|title=Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1|journal=Nature|volume=427|issue=6971|pages=260–265|doi=10.1038/nature02282|issn=1476-4687|pmid=14712238|bibcode=2004Natur.427..260J}}</ref> Ushbu kuzatishlar TRP kanallari harorat va kimyoviy moddalar oralig'ini aniqlashini ko'rsatdi. Devid Yuliyning laboratoriyasi, shuningdek, ushbu kanallarni modulyatsiya qiluvchi toksinlarni topish, turli turlardagi kanallarning noyob moslashuvini [ <ref>{{Cite journal|last=Gracheva|first1=Elena O.|last2=Ingolia|first2=Nicholas T.|last3=Kelly|first3=Yvonne M.|last4=Cordero-Morales|first4=Julio F.|last5=Hollopeter|first5=Gunther|last6=Chesler|first6=Alexander T.|last7=Sánchez|first7=Elda E.|last8=Perez|first8=John C.|last9=Weissman|first9=Jonathan S.|date=April 15, 2010|title=Molecular basis of infrared detection by snakes|journal=Nature|volume=464|issue=7291|pages=1006–1011|doi=10.1038/nature08943|issn=1476-4687|pmc=2855400|pmid=20228791|bibcode=2010Natur.464.1006G}}</ref> <ref>{{Cite journal|last=Bohlen|first1=Christopher J.|last2=Chesler|first2=Alexander T.|last3=Sharif-Naeini|first3=Reza|last4=Medzihradszky|first4=Katalin F.|last5=Zhou|first5=Sharleen|last6=King|first6=David|last7=Sánchez|first7=Elda E.|last8=Burlingame|first8=Alma L.|last9=Basbaum|first9=Allan I.|date=November 16, 2011|title=A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain|journal=Nature|volume=479|issue=7373|pages=410–414|doi=10.1038/nature10607|issn=1476-4687|pmc=3226747|pmid=22094702|bibcode=2011Natur.479..410B}}</ref> tasvirlab, ko'plab kanallarning kriyo-EM tuzilmalarini echish orqali nositseptsiyani o'rganishga o'z hissasini qo'shdi. <ref>{{Cite journal|last=Liao|first1=Maofu|last2=Cao|first2=Erhu|last3=Julius|first3=David|last4=Cheng|first4=Yifan|date=December 5, 2013|title=Structure of the TRPV1 ion channel determined by electron cryo-microscopy|journal=Nature|volume=504|issue=7478|pages=107–112|doi=10.1038/nature12822|issn=1476-4687|pmc=4078027|pmid=24305160|bibcode=2013Natur.504..107L}}</ref> <ref>{{Cite journal|last=Cao|first1=Erhu|last2=Liao|first2=Maofu|last3=Cheng|first3=Yifan|last4=Julius|first4=David|date=December 5, 2013|title=TRPV1 structures in distinct conformations reveal activation mechanisms|journal=Nature|volume=504|issue=7478|pages=113–118|doi=10.1038/nature12823|issn=1476-4687|pmc=4023639|pmid=24305161|bibcode=2013Natur.504..113C}}</ref>

2007–2020 yillarda Yuliy ''“Fiziologiyaning yillik sharhi”'' jurnalining muharriri boʻlib ishlagan. <ref>{{Cite journal|doi=10.1146/annurev.ph.69.013107.100001|title=David Julius for the ARP Editorial Committee|year=2007|last=Julius|first1=David|journal=Annual Review of Physiology|volume=69}}</ref> <ref>{{Veb manbasi|url=https://www.annualreviews.org/db/directory?2020,physiol|sarlavha=Editor of the Annual Review of Physiology - Volume 82, 2020|ish=Annual Reviews|kirish sanasi=26 July 2021}}</ref>

== Mukofotlar ==
2000 yilda Yuliy kapsaitsin retseptorlarini klonlash bo'yicha ishi uchun Neyrologiya bo'yicha Perl-UNC mukofotiga sazovor bo'ldi. 2010 yilda u nositseptsiyaning turli jihatlarida ishtirok etgan [[Ion kanallari|ion kanallarini]] aniqlagan ishi uchun Shou mukofotiga sazovor bo'ldi. 2014 yilda og'riq va termosensatsiyaning molekulyar asoslarini kashf etgani uchun u Jonson &amp;amp; Jonson tomonidan biotibbiyot tadqiqotlari uchun doktor Pol Yanssen mukofoti bilan taqdirlangan. 2017 yilda u Gairdner Foundation xalqaro mukofoti <ref>{{Yangiliklar manbasi |title=David Julius – Gairdner Foundation |language=en-US |work=Gairdner Foundation |url=https://gairdner.org/award_winners/david-julius/ |url-status=live |access-date=November 1, 2018 |archive-url=https://web.archive.org/web/20201022185824/https://gairdner.org/award_winners/david-julius/ |archive-date=October 22, 2020}}</ref> va HFSP Nakasone mukofotini qo'lga kiritdi . <ref>{{Veb manbasi|url=http://www.hfsp.org/awardees/hfsp-nakasone-award/2017-award|sarlavha=The 2017 HFSP Nakasone Award goes to David Julius {{!}} Human Frontier Science Program|ish=www.hfsp.org|til=en|kirish sanasi=November 9, 2018|arxivsana=November 9, 2018|arxivurl=https://web.archive.org/web/20181109070822/http://www.hfsp.org/awardees/hfsp-nakasone-award/2017-award}}</ref> Shuningdek, u texnik va ilmiy tadqiqotlar uchun 2010 yil Asturiya shahzodasi mukofoti, hayot fanlari bo'yicha 2020 yilgi yutuqlar mukofoti <ref>{{Veb manbasi|url=https://breakthroughprize.org/News/54|sarlavha=Breakthrough Prize – Winners Of The 2020 Breakthrough Prize In Life Sciences, Fundamental Physics And Mathematics Announced|ish=breakthroughprize.org|kirish sanasi=October 4, 2021|arxivsana=December 14, 2019|arxivurl=https://web.archive.org/web/20191214131954/https://breakthroughprize.org/News/54}}</ref> va 2020 yil Neyrologiya bo'yicha Kavli mukofoti ( Ardem Patapoutian bilan birgalikda) <ref>{{Veb manbasi|url=http://kavliprize.org/prizes-and-laureates/prizes/2020-kavli-prize-neuroscience|sarlavha=2020 Kavli Prize in Neuroscience|arxivurl=https://web.archive.org/web/20200615081147/http://kavliprize.org/prizes-and-laureates/prizes/2020-kavli-prize-neuroscience|arxivsana=June 15, 2020|ish=www.kavliprize.org|kirish sanasi=2020-05-27}}</ref> va VA BB Jamg'armasi tomonidan 2020 yilgi mukofotlarga sazovor bo'lgan. <ref>{{Veb manbasi|url=https://www.frontiersofknowledgeawards-fbbva.es/|sarlavha=homepage|ish=Premios Fronteras|kirish sanasi=October 4, 2021|arxivsana=September 21, 2021|arxivurl=https://web.archive.org/web/20210921232238/https://www.frontiersofknowledgeawards-fbbva.es/}}</ref>

2021 yilda u harorat va bosim retseptorlarini kashf etgani uchun Ardem Patapoutian bilan birgalikda [[fiziologiya]] yoki [[tibbiyot]] [[Nobel mukofoti|bo'yicha Nobel mukofotiga sazovor]] bo'ldi. <ref>{{Veb manbasi|sarlavha=The Nobel Prize in Physiology or Medicine 2021|url=https://www.nobelprize.org/prizes/medicine/2021/summary/|kirish sanasi=October 4, 2021|ish=NobelPrize.org|til=en-US|arxivsana=October 4, 2021|arxivurl=https://web.archive.org/web/20211004114036/https://www.nobelprize.org/prizes/medicine/2021/press-release/?related=1&_pjax=%23pjax-well}}</ref>

== Manbalar ==
{{Manbalar}}

== Tashqi havolalar ==

* [https://www.ucsf.edu/news/2021/09/421486/biography-david-julius UCSF veb-sayti]
* [https://profiles.ucsf.edu/david.julius UCSF profillari - David Julius]
{{Fiziologiya va tibbiyot boʻyicha Nobel mukofoti laureatlari}}{{2021 Nobel Prize winners}}{{Shaw Prize laureates}}{{Prince of Asturias Award for Technical and Scientific Research}}
[[Turkum:Fiziologiya va tibbiyot boʻyicha Nobel mukofoti sovrindorlari]]
[[Turkum:Fiziologiya va tibbiyot boʻyicha Nobel mukofoti sovrindorlari]]
[[Turkum:Yashayotgan insonlar]]
[[Turkum:Yashayotgan insonlar]]

20-Iyun 2022, 07:58 dagi koʻrinishi

David Julius
Tavalludi 4-noyabr 1955-yil (1955-11-04) (68 yosh)
Brooklyn, New York, U.S.
Fuqaroligi AQSh
Sohasi Physiology
Biochemistry
Neuroscience
Ish joylari University of California, San Francisco
Tezis sarlavhasi Protein processing and secretion in yeast: biosynthesis of α-factor mating pheromone
Akademik rahbarlari Jeremy Thorner
Randy Schekman
Mukofotlari Nobel Prize for Medicine (2021)
Turmush oʻrtogʻi Holly Ingraham

Devid Jey Julius (1955 yil 4-noyabrda tug'ilgan) - amerikalik fiziolog va Nobel mukofoti laureati, og'riq hissi va issiqlikning molekulyar mexanizmlari, shu jumladan kapsaitsin, mentol va haroratni aniqlaydigan TRPV1 va TRPM8 retseptorlarining tavsifi bo'yicha ishi bilan mashhur. U San-Frantsiskodagi Kaliforniya universiteti professori, .

Julius 2010 yilda Hayot haqida fanlar va tibbiyot bo'yicha Shou mukofotini va 2020 yilgi hayot fanlari bo'yicha yutuq mukofotini qo'lga kiritdi. [1] [2] U Ardem Patapoutyan bilan birgalikda fiziologiya yoki tibbiyot bo'yicha 2021 yilgi Nobel mukofotiga sazovor bo'lgan . [3]

Erta hayot va ta'lim

Yuliy Ashkenazilar oilasida ( Rossiyadan ) Brighton Beach, Bruklin, Nyu-York shahrida tug'ilgan [4] u erda Avraam Linkoln o'rta maktabida o'qigan . [5] 1977 yilda Massachusets texnologiya institutida bakalavr darajasini oldi. U 1984 yilda Berkli Kaliforniya universitetida Jeremi Torner va Rendi Shekmanning birgalikdagi rahbarligi ostida doktorlik darajasini oldi, u yerda Kex2 ni furinga o'xshash proprotein konvertazalarining asosi ekanligini aniqladi. 1989 yilda u Kolumbiya universitetida Richard Axel bilan doktorlikdan keyingi ta'limni tugatdi va u yerda serotonin 1c retseptorini klonlash va tavsiflash imkoniga ega bo'ldi. [6]

Berkli va Kolumbiyada bo'lganida, Yuliy silosibin qo'ziqorinlari va lisergik kislota dietilamidining qanday ishlashi bilan qiziqdi, bu esa uni tabiatdagi narsalarning inson retseptorlari bilan o'zaro ta'sirini kengroq o'rganishga olib keldi. [5]

Tadqiqot karerasi

Nobel mukofoti ishi

U oʻz faoliyatini 1989-yilda San-Fransiskodagi Kaliforniya universitetida oʻqituvchi sifatida boshlagan [7] [8] 1997 yilda Yuliyning laboratoriyasi TRPV1 ni klonladi va tavsifladi, bu orqali u chili qalampirini "achchiq" qiladi kapsaitsinni aniqlaydigan retseptorni kashf etdi, . [9] Ular TRPV1 zararli issiqlikni ham aniqlashini aniqladilar ( termotseptsiya ). [9] [10] TRPV1 tizimli ravishda bog'liq bo'lgan TRP (o'tkinchi retseptor potentsiali) kation kanallarining katta oilasining bir qismidir. TRPV1 (oqsilning genetik nokautlari yordamida) yo'q hayvonlar zararli issiqlik va kapsaitsinga sezgirligini yo'qotadi. [11]

Yuliyning laboratoriyasi, shuningdek, TRP super oilasining a'zolari bo'lgan TRPM8 (CMR1) va TRPA1 ni klonladi va tavsifladi. Ular TRPM8 mentol va sovuqroq haroratni aniqlashini [12] [13] va TRPA1 xantal moyini (allil izotiosiyanat) aniqlashini ko'rsatdi. [14] Ushbu kuzatishlar TRP kanallari harorat va kimyoviy moddalar oralig'ini aniqlashini ko'rsatdi. Devid Yuliyning laboratoriyasi, shuningdek, ushbu kanallarni modulyatsiya qiluvchi toksinlarni topish, turli turlardagi kanallarning noyob moslashuvini [ [15] [16] tasvirlab, ko'plab kanallarning kriyo-EM tuzilmalarini echish orqali nositseptsiyani o'rganishga o'z hissasini qo'shdi. [17] [18]

2007–2020 yillarda Yuliy “Fiziologiyaning yillik sharhi” jurnalining muharriri boʻlib ishlagan. [19] [20]

Mukofotlar

2000 yilda Yuliy kapsaitsin retseptorlarini klonlash bo'yicha ishi uchun Neyrologiya bo'yicha Perl-UNC mukofotiga sazovor bo'ldi. 2010 yilda u nositseptsiyaning turli jihatlarida ishtirok etgan ion kanallarini aniqlagan ishi uchun Shou mukofotiga sazovor bo'ldi. 2014 yilda og'riq va termosensatsiyaning molekulyar asoslarini kashf etgani uchun u Jonson &amp; Jonson tomonidan biotibbiyot tadqiqotlari uchun doktor Pol Yanssen mukofoti bilan taqdirlangan. 2017 yilda u Gairdner Foundation xalqaro mukofoti [21] va HFSP Nakasone mukofotini qo'lga kiritdi . [22] Shuningdek, u texnik va ilmiy tadqiqotlar uchun 2010 yil Asturiya shahzodasi mukofoti, hayot fanlari bo'yicha 2020 yilgi yutuqlar mukofoti [23] va 2020 yil Neyrologiya bo'yicha Kavli mukofoti ( Ardem Patapoutian bilan birgalikda) [24] va VA BB Jamg'armasi tomonidan 2020 yilgi mukofotlarga sazovor bo'lgan. [25]

2021 yilda u harorat va bosim retseptorlarini kashf etgani uchun Ardem Patapoutian bilan birgalikda fiziologiya yoki tibbiyot bo'yicha Nobel mukofotiga sazovor bo'ldi. [26]

Manbalar

  1. ↑ „Julius Named to Receive the Shaw Prize“. ucsf.edu. 2019-yil 29-aprelda asl nusxadan arxivlangan. Qaraldi: 2016-yil 5-dekabr.
  2. ↑ „David Julius, PhD 49th Faculty Research Lecture Award“. senate.ucsf.edu. 2020-yil 1-avgustda asl nusxadan arxivlangan. Qaraldi: 2016-yil 5-dekabr.
  3. ↑ „The Nobel Prize in Physiology or Medicine 2021“. NobelPrize.org. 2021-yil 4-oktyabrda asl nusxadan arxivlangan. Qaraldi: 2021-yil 4-oktyabr.
  4. ↑ Hanau. „Scientist David Julius, whose grandparents fled antisemitism in Czarist Russia, wins Nobel Prize in medicine“. Jewish Telegraphic Agency (2021-yil 4-oktyabr). Qaraldi: 2021-yil 4-oktyabr.
  5. ↑ 5,0 5,1 Mueller, Benjamin; Santora, Marc; Engelbrecht, Cora. „Nobel Prize Awarded for Research About Temperature and Touch“. New York Times (2021-yil 4-oktyabr). Qaraldi: 2021-yil 5-oktyabr. Manba xatosi: Invalid <ref> tag; name "nyta" defined multiple times with different content
  6. ↑ Julius, D.; MacDermott, A. B.; Axel, R.; Jessell, T. M. (July 29, 1988). "Molecular characterization of a functional cDNA encoding the serotonin 1c receptor". Science 241 (4865): 558–564. doi:10.1126/science.3399891. ISSN 0036-8075. PMID 3399891. 
  7. ↑ „David Julius '77 shares the Nobel Prize in physiology or medicine“ (en). MIT News | Massachusetts Institute of Technology. Qaraldi: 2021-yil 7-oktyabr.
  8. ↑ „The Nobel Prize in Physiology or Medicine 2021“ (en-US). NobelPrize.org. Qaraldi: 2021-yil 7-oktyabr.
  9. ↑ 9,0 9,1 Caterina, M. J.; Schumacher, M. A.; Tominaga, M.; Rosen, T. A.; Levine, J. D.; Julius, D. (October 23, 1997). "The capsaicin receptor: a heat-activated ion channel in the pain pathway". Nature 389 (6653): 816–824. doi:10.1038/39807. ISSN 0028-0836. PMID 9349813. 
  10. ↑ Tominaga, M.; Caterina, M. J.; Malmberg, A. B.; Rosen, T. A.; Gilbert, H.; Skinner, K.; Raumann, B. E.; Basbaum, A. I. et al. (September 1998). "The cloned capsaicin receptor integrates multiple pain-producing stimuli". Neuron 21 (3): 531–543. doi:10.1016/S0896-6273(00)80564-4. ISSN 0896-6273. PMID 9768840. 
  11. ↑ Caterina, M. J.; Leffler, A.; Malmberg, A. B.; Martin, W. J.; Trafton, J.; Petersen-Zeitz, K. R.; Koltzenburg, M.; Basbaum, A. I. et al. (April 14, 2000). "Impaired nociception and pain sensation in mice lacking the capsaicin receptor". Science 288 (5464): 306–313. doi:10.1126/science.288.5464.306. ISSN 0036-8075. PMID 10764638. 
  12. ↑ McKemy, David D.; Neuhausser, Werner M.; Julius, David (March 7, 2002). "Identification of a cold receptor reveals a general role for TRP channels in thermosensation". Nature 416 (6876): 52–58. doi:10.1038/nature719. ISSN 0028-0836. PMID 11882888. 
  13. ↑ Bautista, Diana M.; Siemens, Jan; Glazer, Joshua M.; Tsuruda, Pamela R.; Basbaum, Allan I.; Stucky, Cheryl L.; Jordt, Sven-Eric; Julius, David (July 12, 2007). "The menthol receptor TRPM8 is the principal detector of environmental cold". Nature 448 (7150): 204–208. doi:10.1038/nature05910. ISSN 1476-4687. PMID 17538622. 
  14. ↑ Jordt, Sven-Eric; Bautista, Diana M.; Chuang, Huai-Hu; McKemy, David D.; Zygmunt, Peter M.; Högestätt, Edward D.; Meng, Ian D.; Julius, David (January 15, 2004). "Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1". Nature 427 (6971): 260–265. doi:10.1038/nature02282. ISSN 1476-4687. PMID 14712238. 
  15. ↑ Gracheva, Elena O.; Ingolia, Nicholas T.; Kelly, Yvonne M.; Cordero-Morales, Julio F.; Hollopeter, Gunther; Chesler, Alexander T.; Sánchez, Elda E.; Perez, John C. et al. (April 15, 2010). "Molecular basis of infrared detection by snakes". Nature 464 (7291): 1006–1011. doi:10.1038/nature08943. ISSN 1476-4687. PMID 20228791. PMC 2855400. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2855400. 
  16. ↑ Bohlen, Christopher J.; Chesler, Alexander T.; Sharif-Naeini, Reza; Medzihradszky, Katalin F.; Zhou, Sharleen; King, David; Sánchez, Elda E.; Burlingame, Alma L. et al. (November 16, 2011). "A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain". Nature 479 (7373): 410–414. doi:10.1038/nature10607. ISSN 1476-4687. PMID 22094702. PMC 3226747. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3226747. 
  17. ↑ Liao, Maofu; Cao, Erhu; Julius, David; Cheng, Yifan (December 5, 2013). "Structure of the TRPV1 ion channel determined by electron cryo-microscopy". Nature 504 (7478): 107–112. doi:10.1038/nature12822. ISSN 1476-4687. PMID 24305160. PMC 4078027. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4078027. 
  18. ↑ Cao, Erhu; Liao, Maofu; Cheng, Yifan; Julius, David (December 5, 2013). "TRPV1 structures in distinct conformations reveal activation mechanisms". Nature 504 (7478): 113–118. doi:10.1038/nature12823. ISSN 1476-4687. PMID 24305161. PMC 4023639. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4023639. 
  19. ↑ Julius, David (2007). "David Julius for the ARP Editorial Committee". Annual Review of Physiology 69. doi:10.1146/annurev.ph.69.013107.100001. 
  20. ↑ „Editor of the Annual Review of Physiology - Volume 82, 2020“. Annual Reviews. Qaraldi: 2021-yil 26-iyul.
  21. ↑ „David Julius – Gairdner Foundation“ (en-US). Gairdner Foundation. 2020-yil 22-oktyabrda asl nusxadan arxivlangan. Qaraldi: 2018-yil 1-noyabr.
  22. ↑ „The 2017 HFSP Nakasone Award goes to David Julius | Human Frontier Science Program“ (en). www.hfsp.org. 2018-yil 9-noyabrda asl nusxadan arxivlangan. Qaraldi: 2018-yil 9-noyabr.
  23. ↑ „Breakthrough Prize – Winners Of The 2020 Breakthrough Prize In Life Sciences, Fundamental Physics And Mathematics Announced“. breakthroughprize.org. 2019-yil 14-dekabrda asl nusxadan arxivlangan. Qaraldi: 2021-yil 4-oktyabr.
  24. ↑ „2020 Kavli Prize in Neuroscience“. www.kavliprize.org. 2020-yil 15-iyunda asl nusxadan arxivlangan. Qaraldi: 2020-yil 27-may.
  25. ↑ „homepage“. Premios Fronteras. 2021-yil 21-sentyabrda asl nusxadan arxivlangan. Qaraldi: 2021-yil 4-oktyabr.
  26. ↑ „The Nobel Prize in Physiology or Medicine 2021“ (en-US). NobelPrize.org. 2021-yil 4-oktyabrda asl nusxadan arxivlangan. Qaraldi: 2021-yil 4-oktyabr.

Tashqi havolalar

Andoza:2021 Nobel Prize winnersAndoza:Shaw Prize laureatesAndoza:Prince of Asturias Award for Technical and Scientific Research

"https://uz.wikipedia.org/w/index.php?title=David_Julius&oldid=2641863" dan olindi